The Reaction of Iodoacetate with Methionine
نویسندگان
چکیده
منابع مشابه
The reaction of iodoacetate with methionine.
lodoacetic acid and its amide have been widely used in protein chemistry as reagents for sulfhydryl groups. Although both can be expected to undergo other reactions with proteins, for example, with the e-amino groups of lysine residues, the imidazole groups of histidine residues, and the phenolic hydroxyls of tyrosine residues, these reactions arc generally slower than is the one with sulfhydry...
متن کاملThe reaction of iodoacetate with ribonuclease-S.
The reaction of iodoacetic acid with ribonuclease has been studied recently by Gundlach et al. (1). Inactivation of the enzyme occurred over a wide range of pH. The authors concluded that at acid pH the reaction involved solely methionyl residues, that at pH 5.5 a histidyl residue was the principal site of attack, and that at alkaline pH values significant reaction at lysyl residues occurred. O...
متن کاملThe reaction of fumarase with iodoacetate and 4-bromocrotonate.
The reaction of fumarase with several alkylating agents has been examined. The structural similarity between these compounds and the natural substrates for the enzyme, fumarate and malate, suggested that reaction might occur with structures in the active sites. Of all the compounds tested, only iodoacetate and 4-bromocrotonate inactivated fumarase by modification of structures other than the th...
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The iodoacetate-nitrogen-poisoned muscle offers the possibility of studying the stoichiometry of the single muscle twitch since metabolic resynthesis by glycolysis and oxidative phosphorylation are blocked, and there remains as an energy source only the creatine phosphoryltransfer system, creatine phosphate reacting with adenosinediphosphate to give the triphosphate and creatine. It is shown, p...
متن کاملdeterminant of the hankel matrix with binomial entries
abstract in this thesis at first we comput the determinant of hankel matrix with enteries a_k (x)=?_(m=0)^k??((2k+2-m)¦(k-m)) x^m ? by using a new operator, ? and by writing and solving differential equation of order two at points x=2 and x=-2 . also we show that this determinant under k-binomial transformation is invariant.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69921-1